Investigation of the frequency and significance of gastric metaplasia in duodenal biopsy materials of untreated pediatric celiac patients

Gastric (foveolar) metaplasia (GM) in the duodenum occurs many cases where duodenitis develops histologically. However, few studies have investigated presence of GM celiac patients. This study aimed to determine prevalence and its relationship with clinicopathological parameters untreated pediatric Duodenal biopsy specimens 153 were analyzed. MUC5AC immunohistochemical staining was applied all detect GM. The patient group evaluated terms disease activity score (DAS), neutrophilic (NAS), eosinophilic infiltration, intramucosal Brunner glands. rate 53.4% control 98.8% group. observed as diffuse morphology at a 4.1% (n:3) 55% (n:44) (p<0.001). Diffuse type more frequent girls (p=0.03). When (focal/diffuse) age, DAS, NAS, histopathological compared, statistically significant difference found between NAS. (p=0.023 p=0.039, respectively). present considered that duodenal neutrophilia increased might play role development We think it would be appropriate include GM, which can easily detected by or histochemical methods, pathology reports finding histologically active disease.